RESUMO
Objective: The study was planned to investigate the role of meaning in life with life satisfaction among women with breast cancer. The study further analyzed the influence of socio-personal characteristics of these women with their life satisfaction. Study Design: Cross sectional survey. Place and Duration of Study: The study was conducted from Sep 2015 to May 2016 on patients selected from different hospitals of Islamabad and Rawalpindi
Material and Methods: A total of 60 patients of breast cancer were enrolled for the said research. The present study used two scales i.e., satisfaction with life scale and meaning of life questionnaires. Snow ball sampling technique was used to collect data of clinical groups from different hospitals of the Punjab
Results: To compare group differences-test analysis was computed. The results showed significant relationship between meaning of life and life satisfaction. The study also found that the low sense of identity as a whole, leads women to be dissatisfied with their lives
Conclusions: This study demonstrated that the level of meaning of life among women with breast cancer is low. Several factors like marital status and education were found to be significantly associated with the meaning in life and life satisfaction of women with breast cancer
RESUMO
Methimazole [MMI] is a widely used drug for hyperthyroidism. However, its clinical use is associated with hepatotoxicity. Though the precise mechanism of hepatic damage is still far from clear, role of metabolic activation and reactive metabolites have been implicated. The present study was designed to investigate the role of enzyme induction in bio activation based hepatotoxicity of methimazole in mice. Thirty male mice were randomly divided into five groups. Hepatotoxicity was induced by single intraperitoneal injection of methimazole [1000mg/kg]. Pretreatment with rifampicin which is a potent enzyme inducer was carried out for 6 days prior to administration of methimazole. The extent of hepatic damage was determined by measuring serum alanine aminotransferase [ALT] and alkaline phosphatase [ALP] along with histopathological grading of liver samples. The elevated levels of biochemical markers by methimazole were potentiated by pretreatment with rifampicin. This potentiation of hepatic injury was also observed in liver histopathological examination. These findings suggest induction of microsomal enzymes as a potentiating factor of methimazole induced hepatotoxicity